Rosalyn Sayaman, PhD

Professional Research Assoc.
Laboratory Medicine
Publications: 

Cell-free DNA concentration as a biomarker of response and recurrence in HER2-negative breast cancer receiving neoadjuvant chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Magbanua MJM, Ahmed Z, Sayaman RW, Brown Swigart L, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Perlmutter J, Pohlmann P, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ

Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells.

Genome research

Senapati P, Miyano M, Sayaman RW, Basam M, Leung A, LaBarge MA, Schones DE

An integrated tumor, immune and microbiome atlas of colon cancer.

Nature medicine

Roelands J, Kuppen PJK, Ahmed EI, Mall R, Masoodi T, Singh P, Monaco G, Raynaud C, de Miranda NFCC, Ferraro L, Carneiro-Lobo TC, Syed N, Rawat A, Awad A, Decock J, Mifsud W, Miller LD, Sherif S, Mohamed MG, Rinchai D, Van den Eynde M, Sayaman RW, Ziv E, Bertucci F, Petkar MA, Lorenz S, Mathew LS, Wang K, Murugesan S, Chaussabel D, Vahrmeijer AL, Wang E, Ceccarelli A, Fakhro KA, Zoppoli G, Ballestrero A, Tollenaar RAEM, Marincola FM, Galon J, Khodor SA, Ceccarelli M, Hendrickx W, Bedognetti D

Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy.

Cancer cell

Magbanua MJM, Brown Swigart L, Ahmed Z, Sayaman RW, Renner D, Kalashnikova E, Hirst GL, Yau C, Wolf DM, Li W, Delson AL, Asare S, Liu MC, Albain K, Chien AJ, Forero-Torres A, Isaacs C, Nanda R, Tripathy D, Rodriguez A, Sethi H, Aleshin A, Rabinowitz M, Perlmutter J, Symmans WF, Yee D, Hylton NM, Esserman LJ, DeMichele AM, Rugo HS, van 't Veer LJ

Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors.

STAR protocols

Sayaman RW, Saad M, Heimann C, Hu D, Kunji K, Roelands J, Wolf DM, Huntsman S, Ceccarelli M, Thorsson V, Ziv E, Bedognetti D

Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility

bioRxiv

Sayaman RW, Miyano M, Senapati P, Zirbes A, Shalabi S, Todhunter ME, Seewaldt V, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA

Comprehensive identification, isolation, and culture of human breast cell types

bioRxiv

Thi K, Del Toro K, Licon-Munoz Y, Sayaman RW, Hines WC

Analysis of germline-driven ancestry-associated gene expression in cancers.

STAR protocols

Chambwe N, Sayaman RW, Hu D, Huntsman S, Cancer Genome Analysis Network, Kemal A, Caesar-Johnson S, Zenklusen JC, Ziv E, Beroukhim R, Cherniack AD

Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies.

Cancer cell

Wolf DM, Yau C, Wulfkuhle J, Brown-Swigart L, Gallagher RI, Lee PRE, Zhu Z, Magbanua MJ, Sayaman R, O'Grady N, Basu A, Delson A, Coppé JP, Lu R, Braun J, I-SPY2 Investigators, Asare SM, Sit L, Matthews JB, Perlmutter J, Hylton N, Liu MC, Pohlmann P, Symmans WF, Rugo HS, Isaacs C, DeMichele AM, Yee D, Berry DA, Pusztai L, Petricoin EF, Hirst GL, Esserman LJ, van 't Veer LJ

Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations.

Nature aging

Shalabi SF, Miyano M, Sayaman RW, Lopez JC, Jokela TA, Todhunter ME, Hinz S, Garbe JC, Stampfer MR, Kessenbrock K, Seewaldt VE, LaBarge MA

Deep proteome profiling of human mammary epithelia at lineage and age resolution.

iScience

Hinz S, Manousopoulou A, Miyano M, Sayaman RW, Aguilera KY, Todhunter ME, Lopez JC, Sohn LL, Wang LD, LaBarge MA

Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression.

Journal of mammary gland biology and neoplasia

Zirbes A, Joseph J, Lopez JC, Sayaman RW, Basam M, Seewaldt VL, LaBarge MA

Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.

Cancer prevention research (Philadelphia, Pa.)

Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA

Epigenetic changes with age primes mammary luminal epithelia for cancer initiation

bioRxiv

Sayaman RW, Miyano M, Senapati P, Shalabi S, Zirbes A, Todhunter ME, Seewaldt V, Neuhausen SL, Stampfer MR, Schones DE, LaBarge MA

Germline genetic contribution to the immune landscape of cancer.

Immunity

Sayaman RW, Saad M, Thorsson V, Hu D, Hendrickx W, Roelands J, Porta-Pardo E, Mokrab Y, Farshidfar F, Kirchhoff T, Sweis RF, Bathe OF, Heimann C, Campbell MJ, Stretch C, Huntsman S, Graff RE, Syed N, Radvanyi L, Shelley S, Wolf D, Marincola FM, Ceccarelli M, Galon J, Ziv E, Bedognetti D

Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry.

NPJ breast cancer

Roelands J, Mall R, Almeer H, Thomas R, Mohamed MG, Bedri S, Al-Bader SB, Junejo K, Ziv E, Sayaman RW, Kuppen PJK, Bedognetti D, Hendrickx W, Decock J

Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.

Cancer cell

Carrot-Zhang J, Chambwe N, Damrauer JS, Knijnenburg TA, Robertson AG, Yau C, Zhou W, Berger AC, Huang KL, Newberg JY, Mashl RJ, Romanel A, Sayaman RW, Demichelis F, Felau I, Frampton GM, Han S, Hoadley KA, Kemal A, Laird PW, Lazar AJ, Le X, Oak N, Shen H, Wong CK, Zenklusen JC, Ziv E, Cancer Genome Atlas Analysis Network, Cherniack AD, Beroukhim R

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications.

Frontiers in oncology

Shan J, Chouchane A, Mokrab Y, Saad M, Boujassoum S, Sayaman RW, Ziv E, Bouaouina N, Remadi Y, Gabbouj S, Roelands J, Ma X, Bedognetti D, Chouchane L

Tissue aging: the integration of collective and variant responses of cells to entropic forces over time.

Current opinion in cell biology

Todhunter ME, Sayaman RW, Miyano M, LaBarge MA

Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells.

Aging

Miyano M, Sayaman RW, Stoiber MH, Lin CH, Stampfer MR, Brown JB, LaBarge MA

Discriminating external and internal causes for heading changes in freely flying Drosophila.

PLoS computational biology

Censi A, Straw AD, Sayaman RW, Murray RM, Dickinson MH

The aerodynamics of hovering flight in Drosophila.

The Journal of experimental biology

Fry SN, Sayaman R, Dickinson MH

The aerodynamics of free-flight maneuvers in Drosophila.

Science (New York, N.Y.)

Fry SN, Sayaman R, Dickinson MH